CLAX antibody, LLT1 antibody, OCIL antibody, Clr-b antibody, Clrb antibody, Ocil antibody, Clec2d5 antibody, CLEC2D antibody, C-type lectin domain family 2 member D antibody, C-type lectin domain family 2, member d antibody, C-type lectin domain family 2, member D antibody, CLEC2D antibody, Clec2d antibody
Background
CLEC2D (C-type lectin domain family 2 member D), also known as LLT1 (lectin-like transcript 1) or OCIL (Osteoclast inhibitory lectin), is a single-pass type II membrane protein expressed by hematopoietic cells and osteoblasts . Its expression was found to be tightly correlated with activation on T cells, NK cells, B cells, and DCs . CLEC2D is a ligand for the human NKR-P1A (CD161) receptor and that their interaction differentially regulates NK- and T-cell functions . It inhibits the formation and function of osteoclasts and modulates the release of interferon-gamma by human NK cells.