BPTF antibody

Catalog No. ABIN7073234

Product Details anti-BPTF Antibody

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BPTF antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Mouse, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Human BPTF

Application Details

Application Notes: IHC/IF (H,M,R) 1:500-1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for BPTF

Target: BPTF (Bromodomain PHD Finger Transcription Factor (BPTF))

Alternative Name: BPTF/FALZ (BPTF Products)

Synonyms: FAC1 antibody, FALZ antibody, NURF301 antibody, 9430093H17Rik antibody, Falz antibody, BPTF antibody, bromodomain PHD finger transcription factor antibody, nucleosome-remodeling factor subunit NURF301 antibody, fetal alzheimer antigen, falz antibody, BPTF antibody, Bptf antibody, LOC5576547 antibody, CpipJ_CPIJ011285 antibody, bptf antibody

Background: FALZ/BPTF is a histone-binding component of NURF (nucleosome remodeling factor), a complex that catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. This gene was identified in brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), containing a DNA-binding domain, a zinc finger motif, and a C-terminal bromodomain, suggested it might play a role in the regulation of transcription during proliferation. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. This protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription.

Gene ID: 2186

NCBI Accession: NP_004450

UniProt: Q12830