WTX antibody

Catalog No. ABIN7073078

Product Details anti-WTX Antibody

Target: WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WTX antibody is un-conjugated

Application: Western Blotting (WB)

Cross-Reactivity: Human, Rat

Purification: Affinity purification

Immunogen: Recombinant protein corresponding to Mouse FAM123B

Application Details

Application Notes: WB (H,M,R) 1: 500-1: 1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, pH 7.4, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for WTX

Target: WTX (AMER1) (APC Membrane Recruitment Protein 1 (AMER1))

Alternative Name: FAM123B (AMER1 Products)

Synonyms: 2810002O09Rik antibody, AW492303 antibody, Fam123b antibody, Wtx antibody, FAM123B antibody, OSCS antibody, WTX antibody, RGD1560322 antibody, fam123b antibody, APC membrane recruitment 1 antibody, APC membrane recruitment protein 1 antibody, Amer1 antibody, AMER1 antibody, amer1 antibody

Background: Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.

Molecular Weight: 125 kDa

Gene ID: 72345

NCBI Accession: NP_780388

UniProt: Q7TS75