Recombinant CXCR2 antibody (N-Term)

Catalog No. ABIN7072664

Product Details anti-CXCR2 Antibody

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Antibody Type: Recombinant Antibody

Binding Specificity: AA 1-30, N-Term

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This CXCR2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Purpose: Anti-IL-8RA [SE2], Rabbit IgG, kappa

Specificity: SE2 antibody is specific for IL-8RA and does not corss-react with IL-8RB. IL-8RA is a receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2b

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunizing BALB/c mice with a BSA-conjugated peptide comprising of the N-terminal part of IL-8RA (amino acids 1-30).

Clone: SE2

Isotype: IgG kappa

Application Details

Application Notes: This antibody is recommended for the detection and analysis of IL-8RA expression. One group used it to identify IL-8RA on the surface of human granulocytes via FACS (Zahn et al., 1997). Importantly, SE2 antibody was specific to IL-8RA-expressing cells only. Subsequent flow cytometric analysis with this antibody led to the characterization of IL-8RA density on human leukocytes (Zahn et al., 1997).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CXCR2

Target: CXCR2 (Chemokine (C-X-C Motif) Receptor 2 (CXCR2))

Alternative Name: IL-8RA (CXCR2 Products)

Background: CXCR-1, C-X-C chemokine receptor type 1, CXC-R1, CDw128a, High affinity interleukin-8 receptor A, IL-8R A, IL-8 receptor type 1, CD181, interleukin 8

UniProt: P25024

Pathways: cAMP Metabolic Process