Recombinant CD96 antibody

Catalog No. ABIN7072566

Product Details anti-CD96 Antibody

Target: CD96

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD96 antibody is un-conjugated

Application: Flow Cytometry (FACS), Blocking Peptide (BP)

Purpose: Anti-CD96 [6A6], Rat IgG2a, lambda

Specificity: This antibody is specific for murine CD96, and recognises an epitope in the first Ig domain.

Characteristics:

Original Species of Ab: Rat

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunising rats with murine CD96.

Clone: 6A6

Isotype: IgG2a lambda

Application Details

Application Notes: This antibody blocks murine CD96-CD155 interaction, and has been shown to bind to the first Ig domain of CD96 and compete with CD155 binding (Roman Aguilera et al, 2018). This antibody displays significant anti-metastatic activity in four experimental lung metastases models and one spontaneous tumour metastasis model (Roman Aguilera et al, 2018), with a potency greater than the anti-CD96 monoclonal antibodies 3.3 and 8B10. The binding specificity of this antibody has been determined in flow cytometric analysis of HEK-293 cells transfected with a range of CD96 Ig domain chimeric constructs (Roman Aguilera et al, 2018).

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for CD96

Target: CD96

Alternative Name: CD96 (CD96 Products)

Background: TACTILE, T-cell surface protein tactile, T cell-activated increased late expression protein

UniProt: Q3U0X8