Recombinant IL9 Receptor antibody

Catalog No. ABIN7072557

Product Details anti-IL9 Receptor Antibody

Target: IL9 Receptor (IL9R) (Interleukin 9 Receptor (IL9R))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Chimeric

Conjugate: This IL9 Receptor antibody is un-conjugated

Application: Immunoprecipitation (IP), Blocking Peptide (BP)

Purpose: Anti-IL-9R [AH9R2], Rabbit IgG, kappa

Specificity: This antibody binds specifically to the human IL-9 receptor alpha chain.

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: This antibody was raised by immunising DBA/2 mice with P815 mastocytoma cells transfected with human IL-9R cDNA.

Clone: AH9R2

Isotype: IgG kappa

Application Details

Application Notes: This antibody has been used to immunoprecipitate human IL-9R expressed by murine BW5147 cells transfected with hIL-9R-encoding cDNA (Demoulin et al, 1996). This antibody binds to and blocks the human IL-9Ra, and displays intermediate inhibitory activity, in a TS1H9RA3 proliferation assay, half-maximal inhibition of 100 pg/mL human IL-9 requires 10 mg/mL of this antibody (de Smedt et al, 2000). Equally, treatment with this antibody partially reduces the cellularity of human thymocytes in chimeric human-mouse FTOC, with no effect on murine thymocytes (de Smedt et al, 2000).

Comment:

This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2b format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for IL9 Receptor

Target: IL9 Receptor (IL9R) (Interleukin 9 Receptor (IL9R))

Alternative Name: IL-9R (IL9R Products)

Background: Interleukin-9 receptor, IL9R, CD129

UniProt: Q01113

Pathways: JAK-STAT Signaling, Growth Factor Binding