Recombinant GPIIb/IIIa antibody
GPIIb/IIIa
Reactivity: Human
ELISA, IF, WB
Host: Rabbit
Chimeric
10E5
unconjugated
Recombinant Antibody
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- Target See all GPIIb/IIIa Antibodies
- GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))
- Antibody Type
- Recombinant Antibody
- Reactivity
- Human
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Host
- Rabbit
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Clonality
- Chimeric
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Conjugate
- This GPIIb/IIIa antibody is un-conjugated
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Application
- ELISA, Immunofluorescence (IF), Western Blotting (WB)
- Purpose
- Anti-GPIIb/IIIa [10E5], Rabbit IgG, kappa
- Specificity
- The antibody binds to GPIIb/IIIa with an affinity (Kd) of 16.2±6 nM. The antibody completely inhibits platelet aggregation at 7.8 μg/mL.
- Characteristics
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Original Species of Ab: Mouse
Original Format of Ab: IgG2a
- Purification
- Protein A affinity purified
- Immunogen
- Human blood platelets.
- Clone
- 10E5
- Isotype
- IgG kappa
- Top Product
- Discover our top product GPIIb/IIIa Primary Antibody
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- Application Notes
- The antibody binds specifically to human GPIIb/IIIa, and integrin complex of membrane glycoproteins expressed on the surface of platelets. The GPIIb/IIIa complex acts as a receptor for fibrinogen and Von Willebran factor, hemostatic glycoproteins that mediate platelet aggregation and blood coagulation. The monoclonal antibody 10E5 inhibits the binding of fibrinogen to its platelet receptor, preventing the platelet aggregation, to be used during coronary artery surgeries such as angioplasty. The antibody is also useful in the study of the disease Glanzmann's thrombasthenia, caused by defects in GPIIb/IIIa, and of immune thrombocytopenic purpura, where autoantibodies are produced against GPIIb/IIIa.
- Comment
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This chimeric rabbit antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % Proclin 300.
- Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- 4 °C,-20 °C
- Storage Comment
- Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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- Target
- GPIIb/IIIa (Platelet Glycoprotein IIb-IIIa Complex (GPIIb/IIIa))
- Alternative Name
- GPIIb/IIIa (GPIIb/IIIa Products)
- Background
- Integrin alpha-IIb/beta-3, Glycoprotein IIb/IIIa, αIIbβ3
- UniProt
- P08514
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