Recombinant PRNP antibody

Catalog No. ABIN7072335

Product Details anti-PRNP Antibody

Target: PRNP (Prion Protein (PRNP))

Antibody Type: Recombinant Antibody

Reactivity: Human, Hamster

Host: Mouse

Clonality: Monoclonal

Conjugate: This PRNP antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Purpose: Anti-Prion [3F4], Mouse IgG1, kappa

Cross-Reactivity: Human

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: IgG2a

Purification: Protein A affinity purified

Immunogen: Hamster 263K PrPs.

Clone: 3F4

Isotype: IgG1 kappa

Application Details

Application Notes: The antibody binds specifically to prion, a misfolded protein that has the ability to enter healthy organisms and cause other misfolding of other proteins into their prion form. This plays an essential role in the pathogenesis of certain neurodegenerative disorders such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Staussler syndrome (GSS) and bovine spongiform encephalopathy (BSE). These disorders are characterised by an accumulation of prion proteins in the brain, which have a disrupted secondary structure.

Comment:

This reformatted mouse antibody was made using the variable domain sequences of the original Mouse IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for PRNP

Target: PRNP (Prion Protein (PRNP))

Alternative Name: Prion (PRNP Products)

Background: Major prion protein, p27-30, CD30 antigen, prion protein PrP, prion-related protein

Pathways: Transition Metal Ion Homeostasis, Activated T Cell Proliferation