Recombinant G Protein-Coupled Receptor 119 antibody

Catalog No. ABIN7072311

Product Details anti-G Protein-Coupled Receptor 119 Antibody

Target: G Protein-Coupled Receptor 119 (GPR119)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat, Dog

Host: Rabbit

Clonality: Chimeric

Conjugate: This G Protein-Coupled Receptor 119 antibody is un-conjugated

Application: ELISA, Immunofluorescence (IF), Blocking Peptide (BP)

Purpose: Anti-Glucose-dependent insulinotropic Receptor [Gipg013], Rabbit IgG, lambda

Specificity: The original has a Ki value of 7 nM and a Kd value of 6.8 nM for human GIPr.

Cross-Reactivity: Dog, Mouse, Rat

Characteristics:

Original Species of Ab: Mouse

Original Format of Ab: scFv

Purification: Protein A affinity purified

Immunogen: Human GIPr.

Clone: Gipg013

Isotype: IgG lambda

Application Details

Application Notes: This antibody binds to GIPr, a GPCR expressed on pancreatic beta-cells, where activation leads to the release of insulin. Endogeonous ligands for the receptor include oleylethanolamide and lysophosphatidylcholine. The antibody acts as a competitive antagonist. In rat islets, the antibody inhibits GIP-induced secretion of insulin by up to 81 % .

Comment:

This full-length, chimeric rabbit antibody was made using the variable domain sequences of the original Mouse scFv format, for improved compatibility with existing reagents, assays and techniques.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % Proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target Details for G Protein-Coupled Receptor 119

Target: G Protein-Coupled Receptor 119 (GPR119)

Alternative Name: Glucose-dependent insulinotropic Receptor (GPR119 Products)

Background: GIPr

UniProt: Q8TDV5

Pathways: Hormone Transport, Peptide Hormone Metabolism