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Phospholamban antibody (pThr17)

PLN Reactivity: Human, Rat, Mouse IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7265288
  • Target See all Phospholamban (PLN) Antibodies
    Phospholamban (PLN)
    Binding Specificity
    • 30
    • 18
    • 17
    • 9
    • 8
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    pThr17
    Reactivity
    • 83
    • 25
    • 24
    • 3
    • 2
    • 2
    • 2
    Human, Rat, Mouse
    Host
    • 83
    • 1
    • 1
    Rabbit
    Clonality
    • 85
    Polyclonal
    Conjugate
    • 32
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Phospholamban antibody is un-conjugated
    Application
    • 34
    • 26
    • 26
    • 24
    • 12
    • 9
    • 9
    • 8
    • 7
    • 6
    • 5
    • 4
    • 1
    • 1
    Immunohistochemistry (IHC)
    Characteristics
    Phosphorylated antibody
    Purification
    Affinity purification
    Immunogen
    A phospho specific peptide corresponding to residues surrounding T17 of human PLN
    Isotype
    IgG
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  • Application Notes
    IHC 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    Phospholamban (PLN)
    Alternative Name
    PLN (PLN Products)
    Synonyms
    LOC100226261 antibody, plb antibody, cmd1p antibody, CMD1P antibody, CMH18 antibody, PLB antibody, Plb antibody, Plm antibody, phospholamban antibody, PLN antibody, pln antibody, Pln antibody
    Background
    The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.
    Gene ID
    5350
    UniProt
    P26678
    Pathways
    Negative Regulation of Transporter Activity
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