Ribonuclease H1 antibody

Catalog No. ABIN7264745

Product Details anti-Ribonuclease H1 Antibody

Target: Ribonuclease H1 (RNASEH1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ribonuclease H1 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human RNASEH1 (NP_002927.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Ribonuclease H1

Target: Ribonuclease H1 (RNASEH1)

Alternative Name: RNASEH1 (RNASEH1 Products)

Synonyms: H1RNA antibody, RNH1 antibody, 74/9 antibody, CG8729 antibody, Dmel\\CG8729 antibody, RNase H1 antibody, RnH1 antibody, l(2)43F1-5 antibody, l(2)43Fa antibody, l(2)k07409 antibody, l(2)k07624 antibody, rnhl antibody, h1rna antibody, rnh1 antibody, zgc:91971 antibody, RNASEH1P1 antibody, RNASEH1 antibody, rnaseh1 antibody, Afu1g10020 antibody, Tb07.26A24.40 antibody, ribonuclease H1 antibody, ribonuclease H1 S homeolog antibody, ribonuclease H1 L homeolog antibody, ribonuclease HI antibody, Ribonuclease H1 antibody, RNASEH1 antibody, Rnaseh1 antibody, rnh1 antibody, rnaseh1.S antibody, rnaseh1 antibody, rnaseh1.L antibody, AFUA_1G10020 antibody, Tb927.7.4930 antibody, APH_RS00510 antibody

Background: This gene encodes an endonuclease that specifically degrades the RNA of RNA-DNA hybrids and is necessary for DNA replication and repair. This enzyme is present in both mitochondria and nuclei, which are resulted from translation of a single mRNA with two in-frame initiation start codons. The use of the first start codon produces the mitochondrial isoform and the use of the second start codon produces the nuclear isoform. The production of the mitochondrial isoform is modulated by an upstream open reading frame (uORF) which overlaps the first initiation start codon in human. An alternately spliced transcript variant has been found which encodes a shorter isoform. This gene has three pseudogenes, two of them are at different locations of chromosome 17 and one of them is on chromosome 1q32.2.

Molecular Weight:

Observed_MW: 37 kDa

Calculated_MW: 32 kDa

Gene ID: 246243

UniProt: O60930