Kcc3 antibody, ACCPN antibody, KCC3 antibody, KCC3A antibody, KCC3B antibody, 9530023I19Rik antibody, gaxp antibody, solute carrier family 12, member 6 antibody, solute carrier family 12 member 6 antibody, Slc12a6 antibody, SLC12A6 antibody
Background
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.