TNK1 antibody (AA 581-666)

Catalog No. ABIN701215

Product Details anti-TNK1 Antibody

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Binding Specificity: AA 581-666

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNK1 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Predicted Reactivity: Human,Mouse,Rat,Cow,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TNK1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TNK1

Target: TNK1 (Tyrosine Kinase, Non-Receptor, 1 (TNK1))

Alternative Name: TNK1 (TNK1 Products)

Synonyms: Kos1 antibody, Tnk1a antibody, Tnk1b antibody, Ack-like antibody, tyrosine kinase non receptor 1 antibody, tyrosine kinase, non-receptor, 1 antibody, TNK1 antibody, Tnk1 antibody

Background:

Synonyms: CD38 negative kinase 1, EC 2.7.10.2 antibody Kinase of embryonic stem cells, Kos 1, Kos1, MGC46193, Non receptor tyrosine protein kinase TNK 1, Non receptor tyrosine protein kinase TNK1, Tnk 1, Tyrosine kinase non receptor 1.

Background: Tnk1 is a nonreceptor protein tyrosine kinase (NRPTK) and a new member of the Ack family of NRPTKs. Tnk1 is a ubiquitously expressed 47- kDa protein with autotyrosine kinase activity that is developmentally regulated during embryogenesis. Tnk1 is also upregulated following IL3 withdrawal from factor-dependent murine NSF/N1.H7 cells that undergo apoptosis, suggesting a role in growth inhibition. Data support a negative regulatory role for Tnk1 in regulating the Ras-Raf1-MAPK growth pathway by a mechanism that requires its autotyrosine kinase activity.

Gene ID: 8711