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PDE6A antibody

PDE6A Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7263957
  • Target See all PDE6A Antibodies
    PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
    Reactivity
    • 23
    • 9
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 23
    Rabbit
    Clonality
    • 23
    Polyclonal
    Conjugate
    • 11
    • 3
    • 3
    • 2
    • 2
    • 2
    This PDE6A antibody is un-conjugated
    Application
    • 21
    • 17
    • 9
    • 4
    • 3
    • 3
    • 3
    Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human PDE6A (NP_000431.2).
    Isotype
    IgG
    Top Product
    Discover our top product PDE6A Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PDE6A (phosphodiesterase 6A, CGMP-Specific, Rod, alpha (PDE6A))
    Alternative Name
    PDE6A (PDE6A Products)
    Synonyms
    si:bz1d10.3 antibody, si:rp71-1d10.3 antibody, CGPR-A antibody, PDEA antibody, RP43 antibody, Pdea antibody, nmf282 antibody, phosphodiesterase 6A, cGMP-specific, rod, alpha antibody, phosphodiesterase 6A antibody, pde6a antibody, PDE6A antibody, Pde6a antibody
    Background
    This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.
    Molecular Weight

    Observed_MW: 120 kDa

    Calculated_MW: 99 kDa

    Gene ID
    5145
    UniProt
    P16499
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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