C79673 antibody, Kindlin3 antibody, RGD1310168 antibody, MGC69069 antibody, MGC88900 antibody, KIND3 antibody, MIG-2 antibody, MIG2B antibody, UNC112C antibody, URP2 antibody, URP2SF antibody, zgc:64101 antibody, fermitin family member 3 antibody, fermitin family member 3 L homeolog antibody, fermitin family member 3b antibody, Fermt3 antibody, fermt3.L antibody, fermt3 antibody, FERMT3 antibody, fermt3b antibody
Background
Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.