1700015E05Rik antibody, AL023058 antibody, C77895 antibody, CaBP5 antibody, P5 antibody, Txndc7 antibody, ERP5 antibody, TXNDC7 antibody, CaBP1 antibody, pdi-p5 antibody, erp5 antibody, pdia6 antibody, pdip5 antibody, txndc7 antibody, protein disulfide isomerase family A member 6 antibody, protein disulfide isomerase associated 6 antibody, protein disulfide isomerase family A, member 6 antibody, protein disulfide isomerase family A member 6 L homeolog antibody, PDIA6 antibody, Pdia6 antibody, pdia6.L antibody
Background
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms.