EIF3C antibody

Catalog No. ABIN7262965

Product Details anti-EIF3C Antibody

Target: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EIF3C antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human EIF3C (NP_003743.1).

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200 IF 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for EIF3C

Target: EIF3C (Eukaryotic Translation Initiation Factor 3 Subunit C (EIF3C))

Alternative Name: EIF3C (EIF3C Products)

Synonyms: eif3s8 antibody, fi37c04 antibody, zgc:66128 antibody, wu:fb34a08 antibody, wu:fi37c04 antibody, EIF3S8 antibody, EIF3CL antibody, eif3-p110 antibody, LOC733086 antibody, eIF3c antibody, eIF3-S8 antibody, AO090011000340 antibody, eIF3-p110 antibody, 110kDa antibody, 3230401O13Rik antibody, Eif3s8 antibody, NIPIL(A3) antibody, NipilA3 antibody, Xs antibody, Xsl antibody, EIF3C antibody, eukaryotic translation initiation factor 3, subunit C antibody, eukaryotic translation initiation factor 3 subunit C antibody, eukaryotic translation initiation factor 3 subunit 8 antibody, Eukaryotic translation initiation factor 3 subunit C antibody, translation initiation factor eIF3c antibody, translation initiation factor eIF-3 subunit 8 antibody, eukaryotic translation initiation factor 3 subunit C L homeolog antibody, eukaryotic translation initiation factor 3, subunit C-like antibody, eif3c antibody, LOC454016 antibody, LOC479795 antibody, EIF3C antibody, Smp_000480 antibody, eIF3c antibody, ANI_1_1094124 antibody, AOR_1_578054 antibody, PTRG_08272 antibody, SJAG_04981 antibody, TERG_03202 antibody, PGTG_09255 antibody, Tsp_05110 antibody, Eif3c antibody, eif3c.L antibody, EIF3CL antibody, eif-3.C antibody

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).

Gene ID: 8663

UniProt: Q99613

Pathways: Ribonucleoprotein Complex Subunit Organization