RGD1563765 antibody, CG2412 antibody, Dm CG2412 antibody, Dmel\\CG2412 antibody, zgc:101596 antibody, RAD51C antibody, Rad51c antibody, ATRAD51C antibody, F4L23.21 antibody, RAS associated with diabetes protein 51C antibody, R51H3 antibody, Rad51l2 antibody, BROVCA3 antibody, FANCO antibody, RAD51L2 antibody, RAD51 paralog C antibody, Rad51 recombinase D antibody, Rad51 DNA recombinase 3 antibody, RAD51C protein antibody, RAD51 homolog C antibody, RAS associated with diabetes protein 51C antibody, RAD51C antibody, Rad51c antibody, Rad51D antibody, rad51c antibody
Background
This gene is a member of the RAD51 family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51 and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with other RAD51 paralogs and is reported to be important for Holliday junction resolution. Mutations in this gene are associated with Fanconi anemia-like syndrome. This gene is one of four localized to a region of chromosome 17q23 where amplification occurs frequently in breast tumors. Overexpression of the four genes during amplification has been observed and suggests a possible role in tumor progression. Alternative splicing results in multiple transcript variants.