RBP3 antibody

Catalog No. ABIN7262218

Product Details anti-RBP3 Antibody

Target: RBP3 (Retinol Binding Protein 3, Interstitial (RBP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBP3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human RBP3 (NP_002891.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:50-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RBP3

Target: RBP3 (Retinol Binding Protein 3, Interstitial (RBP3))

Alternative Name: RBP3 (RBP3 Products)

Synonyms: Irbp antibody, Rbp-3 antibody, D10S64 antibody, D10S65 antibody, D10S66 antibody, IRBP antibody, RBPI antibody, RP66 antibody, retinol binding protein 3 antibody, interphotoreceptor retinoid-binding protein antibody, retinol binding protein 3, interstitial antibody, rbp3 antibody, RBP3 antibody, glr2547 antibody, XOO2681 antibody, AMED_0162 antibody, ambt_08395 antibody, Rbp3 antibody

Background: Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38 % identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.

Molecular Weight:

Observed_MW: 180 kDa

Calculated_MW: 135 kDa

Gene ID: 5949

UniProt: P10745