FBXO11 antibody

Catalog No. ABIN7261998

Product Details anti-FBXO11 Antibody

Target: FBXO11 (F-Box Protein 11 (FBXO11))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO11 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human FBXO11 (NP_001177203.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000 IF 1:20-1:100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FBXO11

Target: FBXO11 (F-Box Protein 11 (FBXO11))

Alternative Name: FBXO11 (FBXO11 Products)

Synonyms: FBX11 antibody, PRMT9 antibody, UBR6 antibody, VIT1 antibody, C80048 antibody, Jf antibody, Vit1 antibody, fbxo11 antibody, MGC84634 antibody, FBXO11 antibody, im:6906507 antibody, wu:fj83f06 antibody, zgc:153171 antibody, Fbxo11 antibody, DKFZp459P2410 antibody, F-box protein 11 antibody, F-box protein 11 L homeolog antibody, F-box protein 11a antibody, F-box only protein 11 antibody, hypothetical protein antibody, FBXO11 antibody, Fbxo11 antibody, fbxo11.L antibody, fbxo11a antibody, CpipJ_CPIJ009919 antibody, CpipJ_CPIJ017549 antibody, Bm1_52225 antibody, LOAG_16571 antibody, fbxo11 antibody, LOC100115478 antibody

Background: This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene.

Molecular Weight:

Observed_MW: 130 kDa

Calculated_MW: 23 kDa/62 kDa/65 kDa/94 kDa/103 kDa/106 kDa

Gene ID: 80204

UniProt: Q86XK2

Pathways: Sensory Perception of Sound