SP100 antibody

Catalog No. ABIN7261812

Product Details anti-SP100 Antibody

Target: SP100 (SP100 Nuclear Antigen (SP100))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SP100 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human SP100 (NP_001193631.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SP100

Target: SP100 (SP100 Nuclear Antigen (SP100))

Alternative Name: SP100 (SP100 Products)

Background: This gene encodes a subnuclear organelle and major component of the PML (promyelocytic leukemia)-SP100 nuclear bodies. PML and SP100 are covalently modified by the SUMO-1 modifier, which is considered crucial to nuclear body interactions. The encoded protein binds heterochromatin proteins and is thought to play a role in tumorigenesis, immunity, and gene regulation. Alternatively spliced variants have been identified for this gene, one of which encodes a high-mobility group protein.

Molecular Weight:

Observed_MW: 66-100 kDa

Calculated_MW: 50 kDa/53 kDa/78 kDa/100 kDa/101 kDa

Gene ID: 6672

UniProt: P23497

Pathways: Retinoic Acid Receptor Signaling Pathway