APLP2 antibody

Catalog No. ABIN7261415

Product Details anti-APLP2 Antibody

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APLP2 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human APLP2 (NP_001135750.1).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for APLP2

Target: APLP2 (Amyloid beta (A4) Precursor-Like Protein 2 (APLP2))

Alternative Name: APLP2 (APLP2 Products)

Synonyms: HAI antibody, MT-SP1 antibody, MTSP1 antibody, PRSS14 antibody, SNC19 antibody, TADG15 antibody, TMPRSS14 antibody, APLP-2 antibody, APPH antibody, APPL2 antibody, CDEBP antibody, AI790698 antibody, Apph antibody, WALPLP2 antibody, aplp2 B antibody, APLP2 antibody, si:dkey-11k4.3 antibody, aplp2 A antibody, MGC86389 antibody, suppression of tumorigenicity 14 antibody, amyloid beta precursor like protein 2 antibody, amyloid beta (A4) precursor-like protein 2 antibody, amyloid beta (A4) precursor-like protein 2 S homeolog antibody, amyloid beta (A4) precursor-like protein 2 L homeolog antibody, ST14 antibody, APLP2 antibody, Aplp2 antibody, aplp2.S antibody, aplp2 antibody, aplp2.L antibody

Background: This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Molecular Weight:

Observed_MW: 87 kDa

Calculated_MW: 59 kDa/79 kDa/80 kDa/85 kDa/86 kDa/87 kDa

Gene ID: 334

UniProt: Q06481

Pathways: EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Feeding Behaviour