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HUS1 antibody

HUS1 Reactivity: Human, Mouse IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7261357
  • Target See all HUS1 Antibodies
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Reactivity
    • 51
    • 28
    • 14
    Human, Mouse
    Host
    • 62
    • 4
    Rabbit
    Clonality
    • 65
    • 1
    Polyclonal
    Conjugate
    • 23
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This HUS1 antibody is un-conjugated
    Application
    • 32
    • 27
    • 13
    • 13
    • 9
    • 9
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human HUS1 (NP_004498.1).
    Isotype
    IgG
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  • Application Notes
    IF 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    HUS1 (HUS1 Checkpoint Homolog (S. Pombe) (HUS1))
    Alternative Name
    HUS1 (HUS1 Products)
    Synonyms
    hHUS1 antibody, mHus1 antibody, XHus1 antibody, hus1 antibody, HUS1 checkpoint clamp component antibody, checkpoint clamp complex protein Hus1 antibody, HUS1 checkpoint clamp component L homeolog antibody, HUS1 antibody, Hus1 antibody, hus1 antibody, hus1.L antibody
    Background
    The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants.
    Gene ID
    3364
    UniProt
    O60921
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