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GRM8 antibody

GRM8 Reactivity: Human, Mouse, Rat WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7260739
  • Target See all GRM8 Antibodies
    GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
    Reactivity
    • 30
    • 22
    • 13
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 27
    • 3
    Rabbit
    Clonality
    • 28
    • 2
    Polyclonal
    Conjugate
    • 18
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This GRM8 antibody is un-conjugated
    Application
    • 18
    • 13
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide of human GRM8
    Isotype
    IgG
    Top Product
    Discover our top product GRM8 Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))
    Alternative Name
    GRM8 (GRM8 Products)
    Synonyms
    mGluR8 antibody, GRM8 antibody, MGLUR8 antibody, GLUR8 antibody, GPRC1H antibody, mGlu8 antibody, A230002O04 antibody, Gprc1h antibody, Glur8 antibody, Mglur8 antibody, mGluR8b antibody, mGlur antibody, glutamate metabotropic receptor 8 antibody, metabotropic glutamate receptor 8 antibody, glutamate receptor, metabotropic 8 antibody, GRM8 antibody, MGLUR8 antibody, LOAG_14062 antibody, Grm8 antibody
    Background
    L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
    Molecular Weight

    Observed_MW: 120 kDa

    Calculated_MW: 55 kDa/101 kDa

    Gene ID
    2918
    UniProt
    O00222
    Pathways
    cAMP Metabolic Process, Synaptic Membrane
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