EST328128 antibody, M-ABC1 antibody, MABC1 antibody, 4833412N02Rik antibody, AA409895 antibody, ABCB8 antibody, zgc:113037 antibody, ATP binding cassette subfamily B member 8 antibody, ATP-binding cassette, sub-family B (MDR/TAP), member 8 antibody, ABCB8 antibody, Abcb8 antibody, abcb8 antibody
Background
This nuclear gene encodes a multi-pass membrane protein that is targeted to the mitochondrial inner membrane. The encoded protein is an ATP-dependent transporter that may mediate the passage of organic and inorganic molecules out of the mitochondria. Loss of function of the related gene in mouse results in a disruption of iron homeostasis between the mitochondria and cytosol. Alternative splicing results in multiple transcript variants.