Dynamitin antibody
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- Target See all Dynamitin (DCTN2) Antibodies
- Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
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Reactivity
- Human, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Dynamitin antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human DCTN2 (NP_006391.1).
- Isotype
- IgG
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- Application Notes
- WB 1:500-1:2000 IHC 1:50-1:200 IF 1:20-1:50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- Dynamitin (DCTN2) (Dynactin 2 (p50) (DCTN2))
- Alternative Name
- DCTN2 (DCTN2 Products)
- Background
- This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 4-5 copies per dynactin molecule. It contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and may affix p150 in place. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
- Molecular Weight
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Observed_MW: 44 kDa
Calculated_MW: 44 kDa
- Gene ID
- 10540
- UniProt
- Q13561
- Pathways
- M Phase, Ribonucleoprotein Complex Subunit Organization
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