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PSMC2 antibody

PSMC2 Reactivity: Human, Mouse, Rat WB, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7260033
  • Target See all PSMC2 Antibodies
    PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))
    Reactivity
    • 39
    • 33
    • 31
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 46
    • 8
    Rabbit
    Clonality
    • 46
    • 7
    Polyclonal
    Conjugate
    • 23
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSMC2 antibody is un-conjugated
    Application
    • 46
    • 23
    • 13
    • 13
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human PSMC2 (NP_002794.1).
    Isotype
    IgG
    Top Product
    Discover our top product PSMC2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000 IHC 1:50-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PSMC2 (Proteasome (Prosome, Macropain) 26S Subunit, ATPase, 2 (PSMC2))
    Alternative Name
    PSMC2 (PSMC2 Products)
    Synonyms
    xMSS1 antibody, psmc2 antibody, DDBDRAFT_0168337 antibody, DDBDRAFT_0232966 antibody, DDB_0168337 antibody, DDB_0232966 antibody, MSS1 antibody, Nbla10058 antibody, S7 antibody, NCU02840.1 antibody, zgc:63995 antibody, proteasome 26S subunit, ATPase 2 L homeolog antibody, proteasome (prosome, macropain) 26S subunit, ATPase 2 antibody, 26S protease regulatory subunit 7 antibody, proteasome 26S subunit, ATPase 2 antibody, regulatory particle, ATPase-like-1 antibody, psmc2.L antibody, psmc2 antibody, psmC2 antibody, PSMC2 antibody, rpt-1 antibody, GL50803_21331 antibody, EHI_080890 antibody, UREG_01412 antibody, PITG_10169 antibody, Psmc2 antibody, GL50803_86683 antibody, Tsp_09237 antibody
    Background
    The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
    Molecular Weight

    Observed_MW: 49 kDa

    Calculated_MW: 33 kDa/48 kDa

    Gene ID
    5701
    UniProt
    P35998
    Pathways
    Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA, Ubiquitin Proteasome Pathway
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