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PITX2 antibody

PITX2 Reactivity: Human, Rat, Mouse WB Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7259893
  • Target See all PITX2 Antibodies
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Reactivity
    • 48
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Rat, Mouse
    Host
    • 42
    • 5
    • 1
    Rabbit
    Clonality
    • 45
    • 3
    Polyclonal
    Conjugate
    • 28
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PITX2 antibody is un-conjugated
    Application
    • 36
    • 28
    • 6
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    A synthetic peptide of human PITX2 (NP_000316.2).
    Isotype
    IgG
    Top Product
    Discover our top product PITX2 Primary Antibody
  • Application Notes
    WB 1:500-1:2000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Alternative Name
    PITX2 (PITX2 Products)
    Background
    This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
    Molecular Weight

    Observed_MW: 39 kDa

    Calculated_MW: 30 kDa/35 kDa

    Gene ID
    5308
    UniProt
    Q99697
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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