Ataxin 2 antibody

Catalog No. ABIN7259314

Product Details anti-Ataxin 2 Antibody

Target: Ataxin 2 (ATXN2)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Ataxin 2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: A synthetic peptide of human ATXN2

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:200 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Ataxin 2

Target: Ataxin 2 (ATXN2)

Alternative Name: ATXN2 (ATXN2 Products)

Synonyms: ASL13 antibody, ATX2 antibody, SCA2 antibody, TNRC13 antibody, 9630045M23Rik antibody, AW544490 antibody, Sca2 antibody, ATXN2 antibody, MGC115230 antibody, ataxin 2 antibody, ataxin 2 L homeolog antibody, ATXN2 antibody, Atxn2 antibody, atxn2.L antibody

Background: This gene belongs to a group of genes that is associated with microsatellite-expansion diseases, a class of neurological and neuromuscular disorders caused by expansion of short stretches of repetitive DNA. The protein encoded by this gene has two globular domains near the N-terminus, one of which contains a clathrin-mediated trans-Golgi signal and an endoplasmic reticulum exit signal. The encoded cytoplasmic protein localizes to the endoplasmic reticulum and plasma membrane, is involved in endocytosis, and modulates mTOR signals, modifying ribosomal translation and mitochondrial function. The N-terminal region of the protein contains a polyglutamine tract of 14-31 residues that can be expanded in the pathogenic state to 32-200 residues. Intermediate length expansions of this tract increase susceptibility to amyotrophic lateral sclerosis, while long expansions of this tract result in spinocerebellar ataxia-2, an autosomal-dominantly inherited, neurodegenerative disorder. Genome-wide association studies indicate that loss-of-function mutations in this gene may be associated with susceptibility to type I diabetes, obesity and hypertension. Alternative splicing results in multiple transcript variants.

Gene ID: 6311

UniProt: Q99700

Pathways: Ribonucleoprotein Complex Subunit Organization