TXNRD1 antibody

Catalog No. ABIN7259296

Product Details anti-TXNRD1 Antibody

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TXNRD1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant protein of human TXNRD1

Isotype: IgG

Application Details

Application Notes: IHC 1:50-1:100 IF 1:50-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TXNRD1

Target: TXNRD1 (Thioredoxin Reductase 1 (TXNRD1))

Alternative Name: TXNRD1 (TXNRD1 Products)

Synonyms: TrxR1 antibody, cb682 antibody, fb83a08 antibody, wu:fb83a08 antibody, GB14972 antibody, MGC85342 antibody, NADPH-dependent thioredoxin reductase C antibody, T32G6.20 antibody, T32G6_20 antibody, GRIM-12 antibody, TR antibody, TR1 antibody, TRXR1 antibody, TXNR antibody, Tr antibody, thioredoxin reductase 1 antibody, thioredoxin reductase 1 L homeolog antibody, NADPH-dependent thioredoxin reductase C antibody, ThioRedoXin Reductase antibody, TXNRD1 antibody, txnrd1 antibody, Trxr-1 antibody, txnrd1.L antibody, NTRC antibody, trxr-1 antibody, Txnrd1 antibody

Background: This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms.

Gene ID: 7296

UniProt: Q16881

Pathways: Regulation of Lipid Metabolism by PPARalpha, Regulation of Carbohydrate Metabolic Process, Cell RedoxHomeostasis