ICAM5 antibody

Catalog No. ABIN7258626

Product Details anti-ICAM5 Antibody

Target: ICAM5 (Intercellular Adhesion Molecule 5 (ICAM5))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ICAM5 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of mouse Icam5 (NP_032345.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for ICAM5

Target: ICAM5 (Intercellular Adhesion Molecule 5 (ICAM5))

Alternative Name: Icam5 (ICAM5 Products)

Synonyms: TLCN antibody, TLN antibody, CD50 antibody, ICAM-3 antibody, Icam3 antibody, Tlcn antibody, ICAM5 antibody, icam5 antibody, tlcn antibody, tln antibody, intercellular adhesion molecule 5 antibody, intercellular adhesion molecule 5, telencephalin antibody, intercellular adhesion molecule 5 L homeolog antibody, ICAM5 antibody, Icam5 antibody, LOC100511183 antibody, icam5.L antibody

Background: ICAM-5, also known as telencephalin, is a type I integral membrane glycoprotein of the immunoglobulin superfamily. It is specifically expressed in the postnatal excitatory neuronal cell bodies, dendritic shafts, and dendritic filopodia of the telencephalon. ICAM-5 functions in both the immune and nervous systems. ICAM-5 strongly stimulates neurite outgrowth. It is cleaved by matrix metalloproteases upon activation of glutamate receptors or degraded through endocytosis resulting in increased spine maturation. The cleaved soluble fragment of ICAM-5 is immunosuppressive, which may be important in neuronal inflammatory diseases.

Molecular Weight:

Observed_MW: 140 kDa

Calculated_MW: 96 kDa

Gene ID: 15898

UniProt: Q60625

Pathways: Cell-Cell Junction Organization, ER-Nucleus Signaling, Maintenance of Protein Location