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CISH antibody

CISH Reactivity: Human, Mouse, Rat IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7257930
  • Target See all CISH Antibodies
    CISH (Cytokine Inducible SH2-Containing Protein (CISH))
    Reactivity
    • 24
    • 16
    • 14
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Human, Mouse, Rat
    Host
    • 24
    • 1
    Rabbit
    Clonality
    • 25
    Polyclonal
    Conjugate
    • 18
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CISH antibody is un-conjugated
    Application
    • 16
    • 6
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human CISH (NP_659508.1).
    Isotype
    IgG
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  • Application Notes
    IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    CISH (Cytokine Inducible SH2-Containing Protein (CISH))
    Alternative Name
    CISH (CISH Products)
    Background
    The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.
    Gene ID
    1154
    UniProt
    Q9NSE2
    Pathways
    JAK-STAT Signaling, Response to Growth Hormone Stimulus
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