HB58 antibody, Hbeta58 antibody, PEP8A antibody, VPS26 antibody, AA407240 antibody, Vps26 antibody, VPS26A antibody, MNC6.7 antibody, MNC6_7 antibody, vacuolar protein sorting 26A antibody, DKFZp459G2011 antibody, hb58 antibody, hbeta58 antibody, pep8a antibody, vps26 antibody, vps26a antibody, wu:fc67e06 antibody, zgc:56673 antibody, VPS26, retromer complex component A antibody, VPS26 retromer complex component A antibody, vacuolar protein sorting 26A antibody, vacuolar protein sorting 26 antibody, vacuolar protein sorting homolog26 antibody, vacuolar protein sorting 26 homolog A (S. pombe) pseudogene antibody, VPS26 retromer complex component A S homeolog antibody, VPS26 retromer complex component A L homeolog antibody, vacuolar protein sorting 26 homolog A (S. pombe) antibody, VPS26A antibody, Vps26a antibody, LOC692917 antibody, vpsh26 antibody, LOC100147400 antibody, vps26a.S antibody, vps26a.L antibody, vps26a antibody
Background
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms.