IQGAP3 antibody

Catalog No. ABIN7257710

Product Details anti-IQGAP3 Antibody

Target: IQGAP3 (IQ Motif Containing GTPase Activating Protein 3 (IQGAP3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IQGAP3 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human IQGAP3 (NP_839943.2).

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IQGAP3

Target: IQGAP3 (IQ Motif Containing GTPase Activating Protein 3 (IQGAP3))

Alternative Name: IQGAP3 (IQGAP3 Products)

Synonyms: IQGAP3 antibody, AI593484 antibody, D030034H08 antibody, IQ motif containing GTPase activating protein 3 antibody, IQGAP3 antibody, iqgap3 antibody, Iqgap3 antibody

Background: IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8 % of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.

Molecular Weight:

Observed_MW: 170 kDa

Calculated_MW: 184 kDa

Gene ID: 128239

UniProt: Q86VI3