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PNP antibody
NP
Reactivity: Human, Mouse
IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-PNP Antibody
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Target
See all PNP (NP) Antibodies
PNP (NP)
(Nucleoside Phosphorylase (NP))
Reactivity
All reactivities for PNP antibodies
Human, Mouse
Host
All hosts for PNP antibodies
Rabbit
Clonality
All clonalities for PNP antibodies
Polyclonal
Conjugate
All conjugates for PNP antibodies
This PNP antibody is un-conjugated
Application
All applications for PNP antibodies
Immunofluorescence (IF)
Characteristics
Polyclonal Antibody
Purification
Affinity purification
Immunogen
Recombinant fusion protein of human PNP (NP_000261.2).
Isotype
IgG
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Discover our top product NP Primary Antibody
Alternatives
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Application Details
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Application Notes
IF 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for PNP
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Target
PNP (NP)
(Nucleoside Phosphorylase (NP))
Alternative Name
PNP (NP Products )
Synonyms
NP antibody, PRO1837 antibody, PUNP antibody, Np antibody, AL024301 antibody, AU015798 antibody, Np-1 antibody, Np-2 antibody, Pnp1 antibody, purine nucleoside phosphorylase antibody, purine-nucleoside phosphorylase antibody, PNP antibody, Pnp antibody
Target Type
Viral Protein
Background
This gene encodes an enzyme which reversibly catalyzes the phosphorolysis of purine nucleosides. The enzyme is trimeric, containing three identical subunits. Mutations which result in nucleoside phosphorylase deficiency result in defective T-cell (cell-mediated) immunity but can also affect B-cell immunity and antibody responses. Neurologic disorders may also be apparent in patients with immune defects. A known polymorphism at aa position 51 that does not affect enzyme activity has been described. A pseudogene has been identified on chromosome 2.
Gene ID
4860
UniProt
P00491
Pathways
Regulation of Leukocyte Mediated Immunity , Positive Regulation of Immune Effector Process , Ribonucleoside Biosynthetic Process , Positive Regulation of Response to DNA Damage Stimulus
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