GNB3 antibody
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- Target See all GNB3 Antibodies
- GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))
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Reactivity
- Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GNB3 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human GNB3 (NP_002066.1).
- Isotype
- IgG
- Top Product
- Discover our top product GNB3 Primary Antibody
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- Application Notes
- WB 1:500-1:2000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- GNB3 (Guanine Nucleotide Binding Protein (G Protein), beta Polypeptide 3 (GNB3))
- Alternative Name
- GNB3 (GNB3 Products)
- Synonyms
- Gnb-3 antibody, MGC68913 antibody, MGC130764 antibody, gnb3 antibody, zgc:73058 antibody, zgc:77780 antibody, wu:fk54b04 antibody, gnb3l antibody, zgc:92641 antibody, G protein subunit beta 3 antibody, guanine nucleotide binding protein (G protein), beta 3 antibody, guanine nucleotide binding protein (G protein), beta polypeptide 3 S homeolog antibody, guanine nucleotide binding protein (G protein), beta polypeptide 3b antibody, guanine nucleotide binding protein (G protein), beta polypeptide 3a antibody, GNB3 antibody, Gnb3 antibody, gnb3.S antibody, gnb3b antibody, gnb3a antibody
- Background
- Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
- Molecular Weight
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Observed_MW: 37 kDa
Calculated_MW: 32 kDa/37 kDa
- Gene ID
- 2784
- UniProt
- P16520
- Pathways
- Peptide Hormone Metabolism, Myometrial Relaxation and Contraction
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