ENT1 antibody, rENT1 antibody, 1200014D21Rik antibody, AA407560 antibody, solute carrier family 29 member 1 (Augustine blood group) antibody, solute carrier family 29 member 1 antibody, solute carrier family 29 (nucleoside transporters), member 1 antibody, SLC29A1 antibody, Slc29a1 antibody
Background
This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.