PDIA2 antibody, DKFZp468D2220 antibody, 1810041F13Rik antibody, AI661267 antibody, Pdip antibody, Pdipl antibody, PDA2 antibody, PDI antibody, PDIP antibody, PDIR antibody, protein disulfide isomerase family A member 2 antibody, protein disulfide isomerase associated 2 antibody, protein disulfide isomerase family A, member 2 antibody, PDIA2 antibody, Pdia2 antibody
Background
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity.