IFT74 antibody

Catalog No. ABIN7256290

Product Details anti-IFT74 Antibody

Target: IFT74 (Intraflagellar Transport Protein 74 Homolog (IFT74))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IFT74 antibody is un-conjugated

Application: Western Blotting (WB)

Characteristics: Polyclonal Antibody

Purification: Affinity purification

Immunogen: Recombinant fusion protein of human IFT74 (NP_001092694.1).

Isotype: IgG

Application Details

Application Notes: WB 1:1000-1:3000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for IFT74

Target: IFT74 (Intraflagellar Transport Protein 74 Homolog (IFT74))

Alternative Name: IFT74 (IFT74 Products)

Background: Capillary morphogenesis protein 1 (CMG1), also known as intraflagellar transport protein 74 (ITP74) or coiled-coil domain-containing protein 2 (CCDC2), is a 600 amino acid human homologue of IFT-71, a complex B protein supporting intraflagellar transport (IFT) in Chlamydomonas. CMG1 localizes to the cytoplasmic vesicle and is highly expressed in adult and fetal kidney and testis, with lower levels of expression in adult heart, placenta, lung, liver and pancreas, and in fetal heart, lung and liver. CMG1 has been suggested to have a role in the primary cilia of HUVEC, and it also functions as a transcriptional regulator of cyclin D2 in spermatocyte-derived cells.

Molecular Weight:

Observed_MW: 80 kDa

Calculated_MW: 42 kDa/69 kDa

Gene ID: 80173

UniProt: Q96LB3

Pathways: Hedgehog Signaling, Chromatin Binding