P-Glycoprotein antibody
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- Target See all P-Glycoprotein products
- P-Glycoprotein
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Reactivity
- Human, Mouse, Rat
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This P-Glycoprotein antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- A synthetic peptide of human P Glycoprotein (NP_000918.2).
- Isotype
- IgG
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anti-P-Glycoprotein antibody
Reactivity: Mouse, Rat WB, IHC Host: Rabbit Polyclonal unconjugated
anti-P-Glycoprotein (AA 647-677) antibodyReactivity: Human WB, ELISA Host: Rabbit Polyclonal unconjugated
anti-P-Glycoprotein (AA 647-677) antibodyReactivity: Human WB Host: Rabbit Polyclonal unconjugated
anti-P-Glycoprotein antibodyReactivity: Human, Hamster WB, IHC, FACS, ICC Host: Mouse Monoclonal JSB-1 unconjugated
anti-P-Glycoprotein antibodyReactivity: Human, Hamster WB, IHC, FACS Host: Mouse Monoclonal JSB-1 unconjugated
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- Application Notes
- IHC 1:50-1:200 IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- P-Glycoprotein
- Alternative Name
- P Glycoprotein (P-Glycoprotein Products)
- Background
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants.
- Gene ID
- 5243
- UniProt
- P08183
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