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PYCARD antibody

PYCARD Reactivity: Human, Mouse, Rat IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7255624
  • Target See all PYCARD Antibodies
    PYCARD (PYD and CARD Domain Containing (PYCARD))
    Reactivity
    • 56
    • 9
    • 8
    • 1
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 47
    • 7
    • 3
    Rabbit
    Clonality
    • 46
    • 11
    Polyclonal
    Conjugate
    • 32
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This PYCARD antibody is un-conjugated
    Application
    • 40
    • 23
    • 14
    • 12
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human ASC / TMS1 (NP_037390.2).
    Isotype
    IgG
    Top Product
    Discover our top product PYCARD Primary Antibody
  • Application Notes
    IHC 1:50-1:200 IF 1:50-1:200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    PYCARD (PYD and CARD Domain Containing (PYCARD))
    Alternative Name
    ASC / TMS1 (PYCARD Products)
    Synonyms
    ASC antibody, CARD5 antibody, TMS antibody, TMS-1 antibody, TMS1 antibody, 9130417A21Rik antibody, Asc antibody, TNS1 antibody, masc antibody, asc1 antibody, zAsc antibody, zgc:109874 antibody, PYD and CARD domain containing antibody, PYCARD antibody, Pycard antibody, pycard antibody
    Background
    This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm, however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
    Gene ID
    29108
    UniProt
    Q9ULZ3
    Pathways
    Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation, Inflammasome
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