CTCF antibody
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- Target See all CTCF Antibodies
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
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Reactivity
- Human, Mouse, Rat, Monkey
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This CTCF antibody is un-conjugated
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Application
- Immunohistochemistry (IHC), Immunofluorescence (IF)
- Characteristics
- Polyclonal Antibody
- Purification
- Affinity purification
- Immunogen
- Recombinant fusion protein of human CTCF (NP_006556.1).
- Isotype
- IgG
- Top Product
- Discover our top product CTCF Primary Antibody
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- Application Notes
- IHC 1:50-1:200 IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C
- Storage Comment
- Store at -20°C. Avoid freeze / thaw cycles.
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- Target
- CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))
- Alternative Name
- CTCF (CTCF Products)
- Synonyms
- im:7152666 antibody, CTCF antibody, xctcf antibody, AW108038 antibody, CCCTC-binding factor antibody, CCCTC-binding factor (zinc finger protein) antibody, CTCF antibody, ctcf antibody, Ctcf antibody
- Background
- This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Gene ID
- 10664
- UniProt
- P49711
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