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HSD17B1 antibody
HSD17B1
Reactivity: Human, Rat, Mouse
IHC, IF
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-HSD17B1 Antibody
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Target
See all HSD17B1 Antibodies
HSD17B1
(Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))
Reactivity
All reactivities for HSD17B1 antibodies
Human, Rat, Mouse
Host
All hosts for HSD17B1 antibodies
Rabbit
Clonality
All clonalities for HSD17B1 antibodies
Polyclonal
Conjugate
All conjugates for HSD17B1 antibodies
This HSD17B1 antibody is un-conjugated
Application
All applications for HSD17B1 antibodies
Immunohistochemistry (IHC), Immunofluorescence (IF)
Characteristics
Polyclonal Antibody
Purification
Affinity purification
Immunogen
Recombinant fusion protein of human HSD17B1 (NP_000404.2).
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
IHC 1:50-1:200 IF 1:50-1:200
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
1 mg/mL
Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
-20 °C
Storage Comment
Store at -20°C. Avoid freeze / thaw cycles.
Target Details for HSD17B1
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Target
HSD17B1
(Hydroxysteroid (17-Beta) Dehydrogenase 1 (HSD17B1))
Alternative Name
HSD17B1 (HSD17B1 Products )
Synonyms
EDH17B2 antibody, EDHB17 antibody, HSD17 antibody, SDR28C1 antibody, 17HSDB1 antibody, 17beta-HSD antibody, E2DH antibody, Hsd17ba antibody, 17BHD1 antibody, zfHSD17B1 antibody, hydroxysteroid 17-beta dehydrogenase 1 antibody, hydroxysteroid (17-beta) dehydrogenase 1 antibody, HSD17B1 antibody, Hsd17b1 antibody, hsd17b1 antibody
Background
Hydroxysteroid (17-beta) dehydrogenase 1 catalyzes the final step in the formation of estradiol and testosterone from estrone and androstenedione, respectively. Ovarian granulosa cells and breast tissue both express HSD17B1. Other tissues that express HSD17B1 include testis, placenta, uterus, prostate and adipose tissue. HSD17B1 functions as a homodimer and prefers NADP(H) over NAD(H) for oxidation and reduction. The gene encoding human HSD17B1 maps to chromosome 17q12-q21. The importance of HSD17B1 to estradiol production suggests the specific inhibition of HSD17B1 may aid in breast cancer therapy.
Gene ID
3292
UniProt
P14061
Pathways
Metabolism of Steroid Hormones and Vitamin D , Steroid Hormone Biosynthesis
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