XAB2 antibody

Catalog No. ABIN7254640

Product Details anti-XAB2 Antibody

Target: XAB2 (XPA Binding Protein 2 (XAB2))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XAB2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Synthetic peptide of human XAB2

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:25-1:100, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.4 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for XAB2

Target: XAB2 (XPA Binding Protein 2 (XAB2))

Alternative Name: XAB2 (XAB2 Products)

Synonyms: Dmel\\CG6197 antibody, Prp5 antibody, XAB2 antibody, Xab2 antibody, zgc:63498 antibody, zgc:63949 antibody, HCNP antibody, HCRN antibody, NTC90 antibody, SYF1 antibody, 0610041O14Rik antibody, AV025587 antibody, Ath55 antibody, fandango antibody, XPA binding protein 2 antibody, XPA binding protein 2 L homeolog antibody, fand antibody, xab2 antibody, XAB2 antibody, xab2.L antibody, Xab2 antibody

Background: HCNP, also known as XAB2 (Xeroderma pigmentosum group A (XPA) binding protein 2), HCRN, SYF1 or NTC90, is a nuclear protein that participates in transcription, transcription-coupled repair (TCR) and pre-mRNA splicing. It contains fifteen tetratricopeptide repeat motifs and associates with nucleotide excision repair machinery. More specifically, HCNP associates with Cockayne syndrome group A and B proteins (CSA and CSB), RNA Polymerase II (Pol II) and XPA in response to DNA damage and is believed to function in the TCR pathway. HCNP also functions as an essential component of a pre-mRNA splicing complex of the spliceosome (composed of AQR (aquarius), PRP19, CCDC16, HCNP, ISY1 and Cyclophilin E) and is required for proper RNA synthesis in the cell. In addition, HCNP functions as a component of the RAR corepressor complex with RAR and HDAC3 and exhibits an inhibitory effect on ATRA-induced cell differentiation. This suggests that HCNP may function as useful target in cancer therapy.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 100 kDa

UniProt: Q9HCS7