Phone:
+1 877 302 8632
Fax:
+1 888 205 9894 (Toll-free)
E-Mail:
orders@antibodies-online.com

SETDB1 antibody

SETDB1 Reactivity: Human, Mouse ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7253431
  • Target See all SETDB1 Antibodies
    SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
    Reactivity
    • 28
    • 18
    • 5
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Mouse
    Host
    • 37
    • 6
    Rabbit
    Clonality
    • 38
    • 5
    Polyclonal
    Conjugate
    • 24
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SETDB1 antibody is un-conjugated
    Application
    • 43
    • 23
    • 13
    • 13
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of human SETDB1
    Isotype
    IgG
    Top Product
    Discover our top product SETDB1 Primary Antibody
  • Application Notes
    IHC 1:50-1:300, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.08 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    SETDB1 (SET Domain, Bifurcated 1 (SETDB1))
    Alternative Name
    SETDB1 (SETDB1 Products)
    Synonyms
    ESET antibody, H3-K9-HMTase4 antibody, KG1T antibody, KMT1E antibody, TDRD21 antibody, AU022152 antibody, mKIAA0067 antibody, SETDB1 antibody, NV10069 antibody, fc07d03 antibody, si:ch211-81a5.6 antibody, wu:fc07d03 antibody, im:7143091 antibody, wu:fa04a12 antibody, wu:fj80h02 antibody, zgc:152899 antibody, SET domain bifurcated 1 antibody, SET domain, bifurcated 1 antibody, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 antibody, histone-lysine N-methyltransferase SETDB1 antibody, SET domain, bifurcated 1a antibody, SET domain bifurcated 1 L homeolog antibody, SET domain, bifurcated 1b antibody, SETDB1 antibody, Setdb1 antibody, MLLT11 antibody, LOC100120014 antibody, LOC100461671 antibody, setdb1a antibody, setdb1.L antibody, setdb1b antibody
    Background
    SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
    UniProt
    Q15047
You are here:
Support