TPMT antibody

Catalog No. ABIN7252816

Product Details anti-TPMT Antibody

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TPMT antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human TPMT

Isotype: IgG

Application Details

Application Notes: IHC 1:40-1:200, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.08 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for TPMT

Target: TPMT (Thiopurine S-Methyltransferase (TPMT))

Alternative Name: TPMT (TPMT Products)

Synonyms: MGC84277 antibody, AW106912 antibody, NHLRC1 antibody, thiopurine S-methyltransferase L homeolog antibody, thiopurine S-methyltransferase, tandem duplicate 2 antibody, thiopurine S-methyltransferase TpmT antibody, thiopurine S-methyltransferase antibody, Thiopurine S-methyltransferase antibody, thiopurine methyltransferase antibody, tpmt.L antibody, tpmt.2 antibody, tpmT antibody, MCA0794 antibody, Pnap_4948 antibody, Hhal_1383 antibody, TK90_1044 antibody, Slit_1144 antibody, Tint_0842 antibody, Fbal_3334 antibody, Celly_3188 antibody, Weevi_1737 antibody, Psefu_2696 antibody, Metme_3860 antibody, Tpmt antibody, TPMT antibody

Background: This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X.

UniProt: P51580