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HLA-DMB antibody

HLA-DMB Reactivity: Human WB, ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7252477
  • Target See all HLA-DMB Antibodies
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Reactivity
    • 42
    • 1
    Human
    Host
    • 39
    • 3
    Rabbit
    Clonality
    • 38
    • 4
    Polyclonal
    Conjugate
    • 22
    • 4
    • 4
    • 4
    • 4
    • 4
    This HLA-DMB antibody is un-conjugated
    Application
    • 41
    • 30
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Characteristics
    Polyclonal Antibody
    Purification
    Antigen affinity purification
    Immunogen
    Fusion protein of human HLA-DMB
    Isotype
    IgG
    Top Product
    Discover our top product HLA-DMB Primary Antibody
  • Application Notes
    WB 1:500-1:2000, IHC 1:30-1:150, ELISA 1:5000-1:10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1.38 mg/mL
    Buffer
    PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    HLA-DMB (Major Histocompatibility Complex, Class II, DM beta (HLA-DMB))
    Alternative Name
    HLA-DMB (HLA-DMB Products)
    Synonyms
    RING7 antibody, D6S221E antibody, RT1.DMb antibody, RT1.Mb antibody, MHC-DMB antibody, major histocompatibility complex, class II, DM beta antibody, RT1 class II, locus DMb antibody, HLA-DMB antibody, RT1-DMb antibody, PATR-DMB antibody
    Background
    HLA-DMB (Major Histocompatibility Complex, Class II, DM Beta) is a Protein Coding gene. Diseases associated with HLA-DMB include Red-Green Color Blindness and Red Color Blindness. Among its related pathways are ICos-ICosL Pathway in T-Helper Cell and CTLA4 Signaling. GO annotations related to this gene include MHC class II protein complex binding. An important paralog of this gene is ENSG00000248993.HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
    Molecular Weight

    Observed_MW: Refer to figures

    Calculated_MW: 29 kDa

    UniProt
    P28068
    Pathways
    Cancer Immune Checkpoints, Human Leukocyte Antigen (HLA) in Adaptive Immune Response
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