UNC45B antibody

Catalog No. ABIN7252228

Product Details anti-UNC45B Antibody

Target: UNC45B (Unc-45 Homolog B (UNC45B))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UNC45B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human UNC45B

Isotype: IgG

Application Details

Application Notes: WB 1:500-1:2000, IHC 1:50-1:300, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.9 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for UNC45B

Target: UNC45B (Unc-45 Homolog B (UNC45B))

Alternative Name: UNC45B (UNC45B Products)

Synonyms: MGC80931 antibody, cmya4 antibody, AA445617 antibody, Cmya4 antibody, D230041A13Rik antibody, Unc45 antibody, CMYA4 antibody, SMUNC45 antibody, UNC45 antibody, Unc-45B antibody, cb393 antibody, unc45r antibody, wu:fa05a03 antibody, wu:fa10f03 antibody, wu:fb37f02 antibody, wu:fb96f06 antibody, wu:fc10f04 antibody, unc-45 myosin chaperone B S homeolog antibody, unc-45 myosin chaperone B antibody, unc45b.S antibody, unc45b antibody, UNC45B antibody, Unc45b antibody

Background: This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants.

Molecular Weight:

Observed_MW: Refer to figures

Calculated_MW: 104/95 kDa

UniProt: Q8IWX7