SPACA3 antibody

Catalog No. ABIN7252069

Product Details anti-SPACA3 Antibody

Target: SPACA3 (Sperm Acrosome Associated Protein 3 (SPACA3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPACA3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Full length fusion protein

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:5000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.5 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for SPACA3

Target: SPACA3 (Sperm Acrosome Associated Protein 3 (SPACA3))

Alternative Name: SPACA3 (SPACA3 Products)

Synonyms: 1700025M08Rik antibody, ALLP17 antibody, CT54 antibody, LYC3 antibody, LYZL3 antibody, SLLP1 antibody, Lyc3 antibody, mSLLP1 antibody, SPRASA antibody, sperm acrosome associated 3 antibody, SPACA3 antibody, Spaca3 antibody

Background: SPACA3 (sperm acrosome associated 3), also known as sperm lysozyme-like protein 1, lysozyme-like protein 3, lysozyme-like acrosomal sperm-specific secretory protein ALLP-17, cancer/testis antigen 54 (CT54), LYC3, SPRASA or LYZL3, is a 215 amino acid protein that participates in the fusion and adhesion of sperm and egg plasma membrane during fertilization. Identified as a novel cancer/testis antigen in hematologic malignancies, SPACA3 has the ability to elicit B-cell immune responses in patients with cancer and is considered a potential target for immunotherapy. A member of the glycosyl hydrolase 22 family which is expressed in testis, placenta and epididymis, SPACA3 exists as two alternatively spliced isoforms, SPACA3 isoform 1 is a single-pass type II membrane protein of the sperm acrosome whereas SPACA3 isoform 2 is a secreted protein. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. It could be a potential receptor for the egg oligosaccharide residue N-acetylglucosamine, which is present in the extracellular matrix over the egg plasma membrane. The processed form has no detectable bacteriolytic activity in vitro.

UniProt: Q8IXA5

Pathways: Glycosaminoglycan Metabolic Process