FKBPL antibody

Catalog No. ABIN7252003

Product Details anti-FKBPL Antibody

Target: FKBPL (FK506 Binding Protein Like (FKBPL))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBPL antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Characteristics: Polyclonal Antibody

Purification: Antigen affinity purification

Immunogen: Fusion protein of human FKBPL

Isotype: IgG

Application Details

Application Notes: IHC 1:30-1:150, ELISA 1:2000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.3 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for FKBPL

Target: FKBPL (FK506 Binding Protein Like (FKBPL))

Alternative Name: FKBPL (FKBPL Products)

Synonyms: FKBPL antibody, ng7 antibody, dir1 antibody, wisp39 antibody, DIR1 antibody, NG7 antibody, WISP39 antibody, Ppiase-X antibody, Wisp39 antibody, FK506 binding protein like antibody, FK506 binding protein-like antibody, FKBPL antibody, fkbpl antibody, Fkbpl antibody

Background: FKBPL,also named as DIR1,NG7 and WISp39,has similarity to the immunophilin protein family,which plays a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This protein is thought to have a potential role in the induced radioresistance,probably by increasing the rate of DNA repair in cells exposed to X rays. Also it appears to have some involvement in general stress response in the control of the cell cycle. It regulates p21 protein stability by binding to Hsp90 and p21. Breast cancer cells stably overexpressing FKBPL became dependent on estrogen for their growth and were dramatically more sensitive to the antiestrogens tamoxifen and fulvestrant,whereas FKBPL knockdown reverses this phenotype. FKBPL is an estrogen-inducible gene that acts as a cochaperone in ERα/Hsp90 Molecular complexes, furthermore,FKBPL levels may be both a prognostic indicator and determinant of response to endocrine therapy.

UniProt: Q9UIM3